AWARD NUMBER: W81XWH-15-1-0256 TITLE: Determine the Dynamic Response to Androgen-Blockade Therapy in Circulating Tumor Cells of CRPC Patients by Transcription-Based Reporter Vectors
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AWARD NUMBER: W81XWH-13-1-0257 TITLE: Coregulation of srGAP1 by Wnt and Androgen Receptor Signaling: A New Target for Treatment of CRPC PRINCIPAL INVESTIGATOR:
Increasing evidence has indicated that Wnt signaling plays complex roles in castration resistant prostate cancer (CRPC). Although not all data were consistent, β-catenin nuclear localization and its co-localization with androgen receptor (AR) were more frequently observed in CRPC compared to hormone naïve prostate cancer. This direct interaction between AR and β-catenin seemed to elicit a speci...
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The treatment effects of the anti-androgen Enzalutamide (ENZ) in patients with castration resistant prostate cancer (CRPC) are short lived. Immunotherapy may improve patient survival, however how efficacious these treatments are for CRPC, particularly those that inhibit T cell checkpoint molecules, remains questionable. Indeed, the lack of PD-L1 expression on CRPC tumors has made rationalizing ...
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Recent clinical advances underscored that elimination of tumor-induced immunosuppression is prerequisite for successful therapy of advanced human cancers. The myeloid-derived suppressor cells (MDSCs) are one of the major populations limiting T cell-mediated antitumor immune responses in late-stage solid tumors, such as castration-resistant prostate cancers (CRPCs). Targeting MDSCs proved challe...
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The androgen receptor (AR) transcription factor plays a key role in the development and progression of prostate cancer, as is evident from the efficacy of androgen-deprivation therapy, AR is also the most frequently mutated gene, in castration resistant prostate cancer (CRPC). AR has therefore become an even more attractive therapeutic target in aggressive and disseminated prostate cancer. To i...
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تاریخ انتشار 2017